Showcase

The research focuses on suppressing the gene in multiple myeloma cancer. The research would compare RNA/DNA modifies sequences to the best fit of ability to suppress the gene. The research can proceed by utilizing and synthesizing novel mirror-image ... nucleic acids and selection/ study of the functional mirror-image RNA/DNA molecules in order to target the RNA-related disease by the process of SELEX (Systematic Evolution of Ligands by Exponential Enrichment). The steps are further continued by researching the development of this mirror-image RNA. DNA structures for the improvement of drug efficiency and biostability before being processed to a candidate for treatment. DNA structures for the improvement of drug efficiency and biostability before being processed to a candidate for treatment. This research is done using RNA aptamers that are incorporated into a selected nanoparticle which will guide the aptamer to cancer cells in the body to deliver gene therapy. We create 3 DNA single strands using the DNA synthesis process and then attach the nanoparticles, aptamers, and siRNAs. My current work involves learning the biochemistry and organic chemistry structures behind these steps while visualizing my supervisor performing these steps with the help of chemicals and the use of laboratory-specific equipment. Read more

The Indiana Fidelity Monitoring Initiative (IFMI) seeks to improve the quality of mental healthcare services and patient outcomes through ensuring that evidence-based practices (EBPs) are delivered as intended (i.e., fidelity) in community behavioral ... health settings. Behavioral health professionals are encouraged to deliver EBPs based on research-backed standards to promote positive clinical outcomes. The clinical field lacks a widely accepted and feasible strategy to routinely measure therapist fidelity to best practice standards. This gap prevents the ability to monitor the quality of services provided in community settings, which limits opportunities to intervene with coaching, training, or other remedies. To address this gap, IFMI strives to establish a statewide procedure to monitor EBP fidelity among community-based behavioral health providers. To guide the development of this statewide program, we conducted interviews with directors of existing national EBP implementation centers and behavioral health professionals. We have collected data on various approaches, challenges, and outcomes of implementing different EBPs and monitoring fidelity. Findings will inform standard operating procedures for IFMI programming. Read more

Dr. Stephen Schlecht, our principal investigator, conducted research on the effect of in vivo fatigue loading on unraveled collagen in the murine anterior cruciate ligament (ACL). The study aimed to understand how the ACL responds to repetitive loadi ... ng and how it affects its structure. The research involved subjecting mice to a series of controlled loading cycles and then analyzing the ACL issues to examine the changes in collagen structure. The results showed that the repetitive loading caused unraveled collagen fibers within the ACL, which may increase the risk of ACL injury. The study is significant because ACL injuries are a common problem, especially among athletes. By understanding the mechanisms of ACL injury, researchers can develop better preventions and treatment strategies. The findings suggest that preventing repetitive loading may help reduce the risk of ACL injuries. Overall, Dr. Schlecht's research provides valuable insights into the effects of repetitive loading on the ACL and highlights the importance of preventative measures to protect against ACL injury. Read more

As part of my role in the Healthy Sleep for Kids Research Laboratory, I have primarily worked on the SLUMBER Study. SLUMBER stands for Sleep Guidance in Black Families with Infant Children, this acronym outlining the premise of the study and its seek ... ing to evaluate and develop safe sleep practices for Black infants and their families because most of the infant sleep practices that have been established have not incorporated feedback from Black families and have not tested the efficacy of these interventions with these families. I have helped refine the interview protocol and have helped transcribe interviews that have been conducted thus far. The progression of the study has equipped me with invaluable learning experiences such as developing my ability to use different research programs, including Redcap surveys and Otter-Artificial Intelligence transcription software, along with providing insight into professional research and what it can involve. Read more

Interested in genetics? What about cancer research? Stop by our table to learn about Dr. Mendonca's Radiation Oncology research. We work with cells that have been altered genetically to test if any particular knockout affects radiation sensitivity. W ... ty. We work with Murine Embryonic Cells (MEF) that have P53-/- , P53 -/- & MDM2 -/- , and P53-/- & MDM2-/- & MDMX -/- knocked out. Come by to learn more and see our results! Read more

The Fodstad Laboratory is an online lab lead by Dr. Fodstad and Jadon Meringer to understand and improve the lives of people with functional and developmental disabilities so that they can receive better care and be more successful.

My internship's focus was involvement in IU Health Simon Cancer Center's Hereditary Renal and Prostate Cancer Clinic. This multidisciplinary clinic focuses on kidney and prostate cancer patients and possible genetic conditions that could have caused ... ave caused their cancer. In this role, I scheduled patients, collected family histories, uploaded information into the research database, mailed patient letters, and helped with sample collection. During the clinic, family history was reviewed, possible risk factors for hereditary cancer syndromes were discussed, and genetic testing was offered. If the patient chose to test, they would get their blood drawn and sent to a lab. When the results were finalized, the patient was contacted to review them. If a patient tested positive, cancer risks and health screening recommendations were discussed. Family members would be recommended to undergo testing to determine if they also carry the gene variant which increases one's risk of cancer. During clinic days, I observed the cases as the healthcare team spoke with patients. This project mainly goes over the importance of that work such as how it affects the patients and their families, the process behind it, and some important conditions tested for which can impact patients and their family's future medical care. Read more

Interested in genetics? What about cancer research? Stop by our table to learn about Dr. Mendonca's Radiation Oncology research. We work with cells that have been altered genetically to test if any particular knockout affects radiation sensitivity. W ... ty. We work with Murine Embryonic Cells (MEF) that have P53-/- , P53 -/- & MDM2 -/- , and P53-/- & MDM2-/- & MDMX -/- knocked out. Come by to learn more and see our results! Read more

Children with autism spectrum disorder (ASD) can be diagnosed before two years of age, but the average age of diagnosis is typically later (over four years old). When children are diagnosed later in life, they can miss early interventions that can im ... prove developmental outcomes. These interventions include applied behavioral analysis, developmental therapy, speech therapy, occupational therapy, and developmental preschool. Along with delays in receiving a diagnosis there comes other difficulties: wait lists, insurance barriers, cost, geographic location and lack of therapists hinder the ability to access intervention services. Community based models of early diagnosis can lead to earlier diagnosis and streamlined access to early interventions and community support. The younger a child can receive their diagnosis, the sooner they can be introduced to pivotal intervention services. The research I participated in studied rates of service enrollment and access barriers for children ages 14-47 months of age at six months after first ASD diagnosis, as well as whether community-based models of diagnosis lead to improved enrollment in intervention that can improve outcomes. Read more

Dexamethasone is a commonly used drug with a variety of uses such as anti-inflammatory and antinausea. In the field of oncology, it is often used to treat nausea and vomiting in chemotherapy and radiation therapy patients. Chemotherapy is highly emet ... ogenic as it attacks rapidly-dividing cells such as those that line the walls of organs in the digestive system. Chemo-induced nausea and vomiting (CINV) is one of the most common, and damaging side effects of chemotherapy. This project is a literature review on the uses and outcomes of dexamethasone as an antiemetic for CINV. CINV affects a patient's ability to do daily activities, nourishment, and overall outcomes by affecting both the patient's body and treatment plan. Chemo is sometimes given further apart due to CINV, this can greatly affect patient outcomes, especially in cases of aggressive forms of cancer. Direct effects of CINV can be fatigue, malnutrition, and dehydration. Dexamethasone is often used in tandem with other antiemetic drugs for the most effective regimen possible. There was a focus in the project on a continuous pump of antiemetics, which allows for preventative and continual treatment of CINV. This allows for a higher tolerance of treatment and better patient outcomes. Read more